27. Guiding principal 27: The protocols submitted to evaluation must comply with all the local MOH /National HIV vaccine committee RCZ, MRCZ, MCAZ, Institutional review boards . GUIDELINES FOR THE SUBMISSION AND EVALUATION OF PROPOSALS AND PROTOCOLS HIV vaccine-related research proposals and protocols must be submitted to the MRCZ , MCAZ, Vaccine Committee and the AIDS and TB Unit before they are implemented. These bodies must verify that the vaccine protocols comply with the national HIV vaccine policy guidelines, evaluate their technical, scientific and ethical aspects as well as register and assess priority ranking and relevance. Terms of reference for a science and ethics committee • Safeguard the dignity, rights, safety and well-being of research participants. • Provide independent, competent and timely review of the research and ethics of proposed studies, in accordance with national guidelines. • Verify ethical integrity of HIV/AIDS vaccine trial protocols in accordance with internationally accepted ethical guidelines, such as: – Declaration of Helsinki – Council for International Organization of Medical Sciences (CIOMS) publication: International Ethical Guidelines for Biomedical Research Involving Human Subjects – World Health Organization (WHO) pamphlet: Proposed International Guidelines for 29